Inspiration for writting Sherlock Holmes

In 1882, Canon Doyle joined former classmate George Budd as his partner at a medical practice in Plymouth, but their relationship proved difficult, and Conan Doyle soon left to set up an independent practice.

Arriving in Portsmouth in June of that year with less than £10 to his name, he set up a medical practice at 1 Bush Villas in Elm Grove, Southsea. The practice was initially not very successful; while waiting for patients, he again began writing stories. His first significant work was A Study in Scarlet, which appeared in Beeton's Christmas Annual for 1887 and featured the first appearance of Sherlock Holmes, who was partially modelled after his former university professor, Joseph Bell. Future short stories featuring Sherlock Holmes were published in the English Strand Magazine. Interestingly, Rudyard Kipling congratulated Conan Doyle on his success, asking "Could this be my old friend, Dr. Joe?"

Sherlock Holmes, however, was even more closely modelled after the famous Edgar Allan Poe character, C. Auguste Dupin.

Killing sherlock holmes:

In November 1891 he wrote to his mother: "I think of slaying Holmes... and winding him up for good and all. He takes my mind from better things." His mother responded, saying, "You may do what you deem fit, but the crowds will not take this lightheartedly." In December 1893, he did so in order to dedicate more of his time to more "important" works.

Holmes and Moriarty apparently plunged to their deaths together down a waterfall in the story, "The Final Problem". Public outcry led him to bring the character back; Conan Doyle returned to the story in "The Adventure of the Empty House", with the explanation that only Moriarty had fallen but, since Holmes had other dangerous enemies, he had arranged to be temporarily "dead" also